Resident Evil 4 Remake - How to Get Handcannon

A guide on how to get the Handcannon for Resident Evil 4 Remake (Biohazard RE 4), including the requirements and conditions to obtain the secret unlockable .50 Magnum Revolver bonus pistol weapon in the remake, weapon type, stats and performance, other gun effects, how to get infinite ammo, and other useful tips. Resident Evil 4 Remake (2023) was released last March 24, 2023, and is now playable on PlayStation 4, PlayStation 5, Xbox Series X|S, and PC via Steam.

Resident Evil 4 Remake (Biohazard RE:4) - How to Get Handcannon

How to Get Handcannon Guide for Resident Evil 4 Remake (Biohazard RE:4)

Resident Evil 4 Remake (Biohazard RE4) - How to Get Handcannon

This page contains a guide on how to get the Handcannon for Resident Evil 4 Remake (Biohazard RE 4), including the requirements and conditions to obtain the secret unlockable .50 Magnum Revolver bonus pistol weapon in the remake, weapon type, stats and performance, other gun effects, how to get infinite ammo, and other useful tips.

Resident Evil 4 Remake (Biohazard RE 4) All Weapons List and Locations

What is the Handcannon?

The Handcannon is a secret obtainable pistol weapon in Resident Evil 4 Remake. It is among the best weapons in game, being able to output massive damage per shot. The Handcannon’s performance truly shines when targeting enemy weak points such as the head or legs. Despite boasting high firepower, the weapon has huge recoil so missing may prove costly, especially when up against powerful foes like the Chainsaw Man, Regenerators, Iron Maidens, and many of the game’s bosses.

Appearance-wise, the Handcannon is essentially a .50 Magnum Revolver and is one of many recurring revolver type pistols throughout the Resident Evil series.

Unlocked by clearing Professional difficulty without using bonus weapons (Primal Knife or Chicago Sweeper)

To get the Handcannon, you must beat the game on Professional difficulty without using the Primal Knife or Chicago Sweeper bonus weapons (must not be in NG+) . To access Professional mode, you will need to complete the main story for the first time on any difficulty. Afterwards, the weapon will become available for purchase from Extra Content Shop (Weapons) by exchanging Challenge Points (CP).

Handcannon Data

Weapon Name Handcannon
Other Names 0.50 Magnum Revolver
Type Pistol
Ammo Ultimate Mighty Z Ammo
Perks Penetration Power
Required Inventory Space 4×2 (to be confirmed)

Handcannon  Stats and Upgrades (Tune Up)

Stats Lv.1 Lv.2 Lv.3 Lv.4 Lv.5
Power 12.0 18.0 24.0 30.0 36.0
Ammo Capacity 5 6 7 8 9
Reload Speed 0.46 2 3 4 6
Rate of Fire 0.52 0.55 0.58 0.61 0.65
Precision 1.80

Handcannon Infinite Ammo

To get infinite ammo for the Handcannon, you must first purchase all tune-up (upgrade) stages for the weapon. Afterwards, the Exclusive weapon upgrade (ammo never runs out) will become available on the tune-up screen. Note that you can skip the initial requirements by purchasing Exclusive Upgrade Tickets using Spinels.

Resident Evil 4 Remake (Biohazard RE 4) How to Get Spinels

Other Gun Effects and Mechanics

Uses Ultimate Mighty Z ammo.

While yet to be confirmed, it is expected that the Handcannon will require Ultimate Mighty Z bullets to use which are quite scarce throughout the game. Because of this, it is recommended to only use the Handcannon for dealing with strong enemies and bosses as the ammo will be wasted on regular foes like the various Ganado roaming the village.

Other Strategy Guides

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Getting Started

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Game Editions DLC List and Guide
How to Claim Pre-Order Bonuses Changes and Differences from the Original
Game Controls Game Difficulty
Permanent Events and Missable Features How Long to Beat the Game
New Gameplay Features Tips for Beginners
Early Access Review Scores Revealed Cut Content List
Is the game coming to Nintendo Switch? Is the game coming to Xbox One?
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Post-Game Unlockables New Game Plus (NG+)

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Trophies and Achievements Best Weapons
Best Mods and Trainers Money Farming Guide
Melee Attacks Guide Parry Guide
All Outfit and Accessory List All Unlockable Characters List
All Boss List and Guides All Merchant Request List and Guide
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How to Repair Knife Durability How to Remove Traps
How to Get Spinels How to Get Chicago Sweeper (Chicago Typewriter)
How to Get Primal Knife How to Get Handcannon
How to Get Rocket Launcher How to Get all Secret Weapons
How to Beat Chainsaw Man Can You Play as Albert Wesker?
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All Collectible Guides

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Treasures List and Locations Weapon List and Locations
Charm List and Locations Yellow Herb List and Locations
Blue Medallion List and Locations -
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All Weapon Guides

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Kitchen Knife Weapon Guide Combat Knife Weapon Guide
SG-09 R Handgun Weapon Guide Red9 Handgun Weapon Guide
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Main Menu

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Merchant Requests and Guides Boss List and Guides
Character List and Guides Collectible List and Guides
Weapon List and Guides Completion Rank Time
Strategy Guides Game Database
Post-Game Unlockables Trophies and Achievements
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