Resident Evil 4 Remake - Permanent Events and Missable Features

Permanent events and missable features guide for Resident Evil 4 Remake (Biohazard RE 4), including all unchangeable choices and points-of-no-return encountered during the game's main story. Resident Evil 4 Remake is set for release on March 24, 2023, for the PlayStation 4, PlayStation 5, Xbox Series X|S, and PC via Steam.

Resident Evil 4 Remake (Biohazard RE:4) - Permanent Events and Missable Features

Permanent Events and Missable Features Guide for Resident Evil 4 Remake

This page contains a guide on all permanent events for Resident Evil 4 Remake (Biohazard RE 4), including all missable features, unchangeable choices, and points-of-no-return encountered during the game’s main story. Be sure to know these gameplay elements when starting a New Game to avoid making major mistakes or get locked out of certain obtainable items, collectibles, and features during your playthrough.

Game difficulty cannot be changed (to be confirmed).

While yet to be confirmed, it is expected that the game difficulty you choose upon starting a New Game cannot be changed afterwards. Because of this, decide carefully which setting you would like to play on based on your current skill and preferences.

Resident Evil 4 Remake (Biohazard RE 4) Game Difficulty Guide

Spinels sold or traded in at the Weapon Merchant’s shop cannot be refunded.

Spinels you collect for clearing Merchant requests or pick up while exploring the various locations of the Los Illuminas village can be exchanged for special items or sold for money (Pesetas) at the Weapons Merchant’s shop. Note that completing transactions involving Spinels is likely to be permanent which means that you cannot refund any of the rare collectibles you offloaded at the shop afterwards.

Resident Evil 4 Remake (Biohazard RE 4) How to Get Spinels

Ingredients and materials used in crafting are lost forever.

Ingredients and materials spent to make healing items, ammo, explosives, and other supplies via crafting are also permanently lost. While many of these crafting materials can be found all throughout the village, it is recommended to avoid wasting any of them and be as efficient as possible with your limited supplies.

Resident Evil 4 Remake (Biohazard RE 4) Crafting Recipes List

Other Strategy Guides

Resident Evil 4 Remake (Biohazard RE:4) - Strategy Guides Banner Resident Evil 4 Remake Strategy (Biohazard RE:4) Guides and Useful Tips

Getting Started

▼All Resident Evil 4 Remake Beginner Guides
Game Editions DLC List and Guide
How to Claim Pre-Order Bonuses Changes and Differences from the Original
Game Controls Game Difficulty
Permanent Events and Missable Features How Long to Beat the Game
New Gameplay Features Tips for Beginners
Early Access Review Scores Revealed Cut Content List
Is the game coming to Nintendo Switch? Is the game coming to Xbox One?
Does Demo Progress Carry Over? Does the Game Support Multiplayer?
How to get a Stable Frame Rate? Hardware Performance Comparisons
Is Separate Ways Available in the Game? Best Gameplay Settings for Beginners and Experienced Players
All Character List Voice Actor List
Post-Game Unlockables New Game Plus (NG+)

Demo Guides

▼All Resident Evil 4 Remake Demo Guides
All Hidden Features (Demo) How to Get TMP (Demo)
How to Get Kitchen Knife (Demo) How to Unlock Mad Chainsaw Difficulty (Demo)

All Useful Guides

▼All Resident Evil 4 Remake Useful Guides
Trophies and Achievements Best Weapons
Best Mods and Trainers Money Farming Guide
Melee Attacks Guide Parry Guide
All Outfit and Accessory List All Unlockable Characters List
All Boss List and Guides All Merchant Request List and Guide
All Collectibles List and Guides All Completion Rank Time Requirements and Rewards
Crafting Recipes and Ingredients How to Unlock Mercenaries Mode
How to Increase Maximum Health How to Increase Attache Case Storage
How to Unlock Mafia Outfit (Leon) How to Unlock Knight Armor Outfit (Ashley)
How to Repair Knife Durability How to Remove Traps
How to Get Spinels How to Get Chicago Sweeper (Chicago Typewriter)
How to Get Primal Knife How to Get Handcannon
How to Get Rocket Launcher How to Get all Secret Weapons
How to Beat Chainsaw Man Can You Play as Albert Wesker?
Can You Kill the Merchant? -
Resident Evil 4 Remake (Biohazard RE:4) - Collectibles Banner Resident Evil 4 Remake (Biohazard RE:4) Collectibles List and Guides

All Collectible Guides

▼All Resident Evil 4 Remake Collectible Guides
File List and Locations Clockwork Castellan List and Locations
Treasures List and Locations Weapon List and Locations
Charm List and Locations Yellow Herb List and Locations
Blue Medallion List and Locations -
Resident Evil 4 Remake (Biohazard RE:4) - Weapon Guides Banner Resident Evil 4 Remake (Biohazard RE:4) Weapon List and Guides

All Weapon Guides

▼All Resident Evil 4 Remake Weapon Guides
Kitchen Knife Weapon Guide Combat Knife Weapon Guide
SG-09 R Handgun Weapon Guide Red9 Handgun Weapon Guide
Punisher Handgun Weapon Guide Sentinel Nine Handgun Weapon Guide
W870 Shotgun Weapon Guide Skull Shaker Shotgun Weapon Guide
TMP Submachine Gun Weapon Guide -

Resident Evil 4 Remake Recommended Article List

Resident Evil 4 Remake (Biohazard RE:4) - Game Category Banner Resident Evil 4 Remake (Biohazard RE:4) Walkthrough and Guide

Main Menu

▼Resident Evil 4 Remake Recommended Articles
Merchant Requests and Guides Boss List and Guides
Character List and Guides Collectible List and Guides
Weapon List and Guides Completion Rank Time
Strategy Guides Game Database
Post-Game Unlockables Trophies and Achievements
Resident Evil 4 Remake (Biohazard RE:4) - Capcom Guides Banner

Resident Evil Series

▼All Resident Evil Series Game Guides
Resident Evil 3 Remake - Game Category BannerResident Evil 3 Remake Resident Evil 4 Remake - Game Category BannerResident Evil 4 Remake
Resident Evil 3 Remake - Game Category BannerResident Evil 7 Biohazard -

Devil May Cry Series

▼All Devil May Cry Series Game Guides
Devil May Cry 5 - Game Category BannerDevil May Cry 5 -

Monster Hunter Series

▼All Monster Hunter Series Game Guides
Monster Hunter World: Iceborne - Game Category BannerMonster Hunter World: Iceborne Monster Hunter Rise - Game Category BannerMonster Hunter Rise

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