Resident Evil 4 Remake - Permanent Events and Missable Features

Permanent Events and Missable Features Guide for Resident Evil 4 Remake

This page contains a guide on all permanent events for Resident Evil 4 Remake (Biohazard RE 4), including all missable features, unchangeable choices, and points-of-no-return encountered during the game’s main story. Be sure to know these gameplay elements when starting a New Game to avoid making major mistakes or get locked out of certain obtainable items, collectibles, and features during your playthrough.

Game difficulty cannot be changed (to be confirmed).

While yet to be confirmed, it is expected that the game difficulty you choose upon starting a New Game cannot be changed afterwards. Because of this, decide carefully which setting you would like to play on based on your current skill and preferences.

Resident Evil 4 Remake (Biohazard RE 4) Game Difficulty Guide

Spinels sold or traded in at the Weapon Merchant’s shop cannot be refunded.

Spinels you collect for clearing Merchant requests or pick up while exploring the various locations of the Los Illuminas village can be exchanged for special items or sold for money (Pesetas) at the Weapons Merchant’s shop. Note that completing transactions involving Spinels is likely to be permanent which means that you cannot refund any of the rare collectibles you offloaded at the shop afterwards.

Resident Evil 4 Remake (Biohazard RE 4) How to Get Spinels

Ingredients and materials used in crafting are lost forever.

Ingredients and materials spent to make healing items, ammo, explosives, and other supplies via crafting are also permanently lost. While many of these crafting materials can be found all throughout the village, it is recommended to avoid wasting any of them and be as efficient as possible with your limited supplies.

Resident Evil 4 Remake (Biohazard RE 4) Crafting Recipes List

Other Strategy Guides

Getting Started

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Resident Evil 4 Remake Recommended Article List

Main Menu

Resident Evil Series

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Resident Evil 3 Remake	Resident Evil 4 Remake
Resident Evil 7 Biohazard	-

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Devil May Cry 5	-

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Monster Hunter World: Iceborne	Monster Hunter Rise