Resident Evil 3 Remake Nemesis Final Boss Guide
When the fight begins, quickly move to the rotting piles to your left to grab First Aid Spray and Handgun Ammo. Turn around and fix your camera on Nemesis to anticipate his attacks.
Nemesis has very noticeable tells when he is about to strike. He will wind up his arm to perform either a wide-rang swipe or a downward crush. He will also briefly pump both arms on the ground before lunging at you to bind you.
A good strategy to use against him is to bait him into throwing out attacks. Stay on the move while strafing to the side to create some distance from him. After he swings and misses, pepper him with shots. Your window to damage him is usually enough for about three shots using a shotgun before you should go on the defensive again. Timing your dodge is also a good way to avoid Nemesis’ attacks, especially his lunge.
You can grab more items from the rotting piles as the fight drags on.
After doing enough damage, Carlos will arrive. Nemesis will hide in one of the tanks above as zombies appear in the area. Listen to Carlos to find a out which tank Nemesis is hiding behind and shoot its two glowing panels to damage the boss. This leave him open for follow-up attacks before he can retaliate. You can quickly take out the zombies that appear before Carlos gives Nemesis’ position. Note that taking too long to shoot the tank also allows Nemesis to ambush you. As the fight progresses, you will need to shoot the panels faster as the boss will give you less time to do so before it strikes from above.
After the cutscene, proceed ahead to the staff break room. You can save your game here if you want. You can use the item box on the right to restock on items and ammo as well. Afterwards, head to the door past the typewriter and follow the walkway. After another cutscene, get ready to take on Nemesis one last time.
When the fight begins, turn around and use the railgun to fire at the boss. Afterwards, you will need to charge the gun again by pushing the red power cores into the wall.
Nemesis has a number of attacks in this phase. He will shoot acidic gas that damages you when you come in contact with it. He can also perform massive swipes with his arms that can be avoided with a well timed dodge. These make it harder to push the power cores into the wall.
To give you time to push the cores, shoot the glowing circular masses growing on Nemesis using the grenade launcher. After you take them out, Nemesis will be knocked out momentarily. Be careful as his massive body falling to the ground can damage you if you are within range. After you have pushed all power cores into the wall, the railgun will be usable again. Fire it to finish off Nemesis.