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Guide on How to Defeat Mephisto in Shin Megami Tensei V
Mephisto is a DLC subquest boss enemy faced by the Protagonist or Nahobino in Shin Megami Tensei V (SMT 5). The demon is encountered at Da’at’s Minato Region.
How to face Mephisto
In order to face Mephisto in battle, start the DLC subquest: “The Doctor’s Last Wish”. Return to Minato Region’s Tokyo Diet building and speak to a researcher. Offer your services and speak to another researcher nearby to start the subquest. Transfer to Kamiyacho Leyline Crossing and speak to Mephisto on the top of a building northwest. The battle will start immediately against the boss. Make sure to save your game before the boss fight.
The Doctor’s Last Wish Subquest Walkthrough
Mephisto Boss Information
Mephisto Demon Stats and Skills
Here is a breakdown of the boss’ stats, strengths and weaknesses, and skills:
|Boss Type||Optional Boss (DLC Subquest)|
|Recommended Level||Level 79 or higher|
|Recommended Party Members||? or any ally demons|
|Macca Rewards||? Macca|
|Other Rewards||? items|
Mephisto Strength and Weaknesses
|Walpurgisnacht +9||Severe Dark attack to 1 foe. Chance of instakill when striking weakness.|
|Brave Blade +7||Heavy Physical attack to 1 foe. High chance of Critical.|
|Agibarion +7||Severe Fire attack to 1 foe.|
|Makajamaon +9||Chance of inflicting Seal to all foes.|
|Luster Candy +4||Raises all stats of all allies by 1 rank for 3 turns.|
|Impaler’s Animus +4||Increases the damage of the next attack and adds Pierce effect for self.|
|Stagnant Air +9||Chance of inflicting Mirage to all foes and lowers Defense and Accuracy/Evasion by 1 rank for 3 turns.|
|Mamudobarion +9||Severe Dark attack to all foes. Chance of instakill when striking weakness.|
|Omagatoki: Critical||All attacks, including magical attacks, will become Critical hits for all allies for 1 turn.|
Mephisto Boss Setup
Here is a breakdown of the battle preparation against the boss:
Carry HP and MP recovery items
Before engaging the boss, bring HP and MP recovery items in case your party runs out of HP and MP during battle. Also, don’t forget Ailment recovery items such as Amrita Soda.
Max your Magatsuhi Gauge
In addition, make sure that your Magatsuhi gauge is already maxed. Having it maxed prior to battle is helpful in setting up your offense. Also, having a Miracle skill, Magatsuhi Wellspring, will provide your party HP and MP recovery at the start of your party’s turn.
Assign Nahobino Light skills
Make sure to import Light skills if you can in order to exploit the weakness of the boss. Otherwise, you can rely on your ally demons to have those skills for you. To add, complement your offense with strength-based elemental skills such as White Dracostrike.
Furthermore, put in Support and Passive skills to boost damage if there are still skill slots remaining. Recovery skills are optional if your active party members do not have these skills. This is to sustain the party during battle.
Attach resistances to Nahobino that nullify Phys, Fire, Dark, and Ailment skills
With the Divine Amalgamation Miracle, Nahobino can implant new resistances from essences. Add to Nahobino resistances that can Reflect/Absorb/Void/Resist Physical, Fire, Dark, and Ailment skills.
Pick ally demons that can counter Phys, Fire, Dark, and Ailment skills
Bring party members can innately Reflect/Absorb/Void/Resist Physical, Fire, Dark, and Ailment skills if possible. If you can’t, make it a point that their weaknesses are covered during battle. You can make use of Physical, Fire, Dark, and Ailment Block skills or make use of Dampener items.
Add demons that can use Light skills
Similarly, add demons to your active party that can use Light skills. If they don’t have access to those skills, utilize Essence Fusion to grab those skills from demon essences.
Mephisto Boss Strategies
Here is a breakdown of the battle strategies against the boss:
Pass action to support demons
If you start the battle with Nahobino and don’t have access to debuff/buff Support skills, make use of the Press Turn System and pass your turn to demon allies that can use debuff Support skills.
Land debuffs on the boss while leaving some MP for offense and recovery. Debuffs are in the form of attack power decrease (Tarunda), defense power decrease (Rakunda), and hit/evasion power decrease (Sukunda). In addition to these Support skills, you can utilize skills from other types such as Fang Breaker (Tarunda), Pierce Armor (Rakunda), Toxic Spray (Rakunda), and Blinding Strike (Sukunda) to cast similar effects. These debuffs can be accessed by Nahobino and any demons in your party.
Prioritize on landing Sukunda first. Followed by Tarunda and Rakunda. Since the boss will keep on using its Luster Candy skill, land -nda debuffs again or Dekaja to nullify its effect during battle.
Cast buffs on your party members as well. Buffs can be in the form of attack power increase (Tarukaja/Matarukaja), defense power increase (Rakukaja/Marakukaja), and hit/evasion power increase (Sukukaja/Masukukaja). These buffs can be accessed by Nahobino and any demons in your party.
Prioritize on landing Sukukaja/Masukukaja first. Followed by Rakukaja/Marakukaja and Tarukaja/Matarukaja. You may also use Charge/Donum Gladi and Concentrate/Donum Magici buffs to boost your party’s damage even further if available. Since the boss will keep on using its Stagnant Air skill against your party, cast -kaja buffs again or Dekunda to remove its effect during battle.
Cure Seal and Mirage Ailments inflicted to the party
If a party member got inflicted with an Ailment such as Seal and Mirage, make sure that you have access to Ailment recovery skills such as Patra or Me Patra to cure it. You can also use status recovery items such as Amrita Soda to remove them if available. Ailment recovery skills can be accessed by Nahobino and any demons in your party.
Use Block skills and Dampener items to void enemy skills
Before using a Magatsuhi skill in your next turn, you can use a Block skill or a Dampener item to nullify the enemy’s upcoming attack. You can prioritize voiding Fire and Dark since the boss has a multi-target skill on it. Once the attack misses, it will consume an additional press turn resulting in fewer actions. Take note that you can only block one affinity or element per turn and it is not stackable.
Activate Magatsuhi skill
Unleash the Magatsuhi skill such as Omagatoki: Critical to boost your damage even further. Make sure to use it once debuffs and buffs are already set. Activate the Magatsuhi skill on Nahobino’s turn and you will have up to 8 possible actions against the boss.
If you already unlocked the Race Transcendence Miracle skill, you can also use other Magatsuhi skills held by other party members.
Use Light skills against Mephisto
Mephisto is weak against Light skills which Nahobino and his ally demons can capitalize on. The damage will be higher if the party is buffed with Tarukaja/Matarukaja and Concentrate/Donum Magici.
If you are setting up for White Dracostrike, cast Charge/Donum Gladi instead to boost the damage.
Keep the party’s HP sustained by using healing skills. Especially when other party members are getting overwhelmed by enemy damage.
Mephisto Boss Video
Here is a boss fight video against Mephisto. The battle is already timestamped so you no longer need to browse through the whole video:
Other BossesBoss Guides (Boss List)
SMT V Minato Region Bosses
|Drake Hydra (Level 15)||Fallen Eligor (Level 20)|
|Lady Nuwa (Level 22)||-|
|Vile Pazuzu (Level 16)||Yoma Apsaras (Level 16)|
|Femme Leanan Sidhe (Level 17)||Brute Oni (Level 17)|
|Megami Anahita (Level 18)||Brute Shiki-Ouji (Level 19)|
|Dragon Xuanwu / Genbu (Level 23)||Avian Jatayu (Level 25)|
|Holy Baihu / Byakko (Level 43)||Avian Zhuque / Suzaku (Level 43)|
|Kishin Koumokuten Part 1 (Level 44)||Dragon Qing Long / Seiryu (Level 45)|
|Kunitsu Oyamatsumi (Level 48)||Drake Seth (Level 62)|
|Deity Khonsu (Level 64)||Kishin Koumokuten Part 2 (Level 65)|
|Dragon Huang Long / Kohryu (Level 70)||Fury Zaou-Gongen (Level 75)|
SMT V Shinagawa Region Bosses
|Vile Lahmu Part 1 (Level 23)||Beast Loup-garou (Level 28)|
|Genma Fionn mac Cumhaill Part 1 (Level 32)||Vile Lahmu Part 2 (Level 38)|
|Tyrant King Frost (Level 28)||Divine Principality (Level 28)|
|Night Lilim (Level 32)||Haunt Kumbhanda (Level 34)|
|Avian Thunderbird (Level 35)||Tyrant Loki (Level 36)|
|Kishin Zouchouten Part 1 (Level 36)||Tyrant Belphegor (Level 38)|
|Vile Girimekhala (Level 46)||Genma Amanozako (Level 51)|
|Kunitsu Arahabaki (Level 62)||Kishin Zouchouten Part 2 (Level 65)|
|Deity Baal (Level 69)||Deity Khonsu Ra (Level 82)|
SMT V Chiyoda Region Bosses
|Meta Shohei Yakumo (Level 46)||Tyrant Surt (Level 49)|
|Lady Ishtar (Level 52)||Fury Chernobog (Level 53)|
|Tyrant Arioch (Level 55)||Herald Abdiel (Level 58)|
|Fury Dionysus (Level 44)||Night Black Frost (Level 44)|
|Deity Horus (Level 46)||Jaki Hecatoncheires (Level 47)|
|Holy Chimera (Level 50)||Kunitsu Okuninushi, Oyamatsumi, Sukuna-Hikona, and Take-Minakata (Level 39-50)|
|Kishin Jikokuten Part 1 (Level 51)||Tyrant Moloch (Level 51)|
|Herald Camael (Level 54)||Kishin Jikokuten Part 2 (Level 65)|
|Fury Asura and Tyrant Mithras (Level 71)||-|
SMT V Taito Region Bosses
|Deity Zeus Part 1 (Level 72)||Drake Vasuki (Level 72)|
|Deity Odin (Level 72)||Herald Metatron (Level 78)|
|Herald Melchizedek (Level 79)||Herald Sraosha (Level 80)|
|Lady Alilat (Level 81)||Nahobino Abdiel (Level 83)|
|Nahobino Tsukiyomi (Level 83)||Nahobino Nuwa (Level 83)|
|Matter Lucifer (Law and Chaos Route) (Level 85)||Matter Lucifer (True Neutral/Humanity Route) (Level 90)|
|Kishin Bishamonten Part 1 (Level 58)||Tyrant Abaddon (Level 61)|
|Kishin Bishamonten Part 2 (Level 65)||Genma Fionn mac Cumhaill Part 2 (Level 66)|
|Wargod Futsunushi (Level 69)||Fallen Adramelech (Level 71)|
|Tyrant Amon (Level 73)||Herald Raphael, Gabriel, and Uriel (Level 74)|
|Avian Garuda (Level 80)||Herald Michael (Level 80)|
|Tyrant Belial (Level 80)||Megami Maria (Level 81)|
|Lady Inanna (Level 81)||Lady Danu (Level 81)|
|Deity Zeus Part 2 (Level 86)||Fury Shiva (Level 96)|
SMT V DLC Bosses
|Dragon Quetzalcoatl (Level 34)||Megami Artemis (Level 37)|
|Femme Cleopatra (Level 61)||Tyrant Mephisto (Level 79)|
|Fiend Matador (Level 24)||Fiend Daisoujou (Level 30)|
|Fiend Hell Biker (Level 36)||Fiend White Rider (Level 43)|
|Fiend Red Rider (Level 47)||Fiend Black Rider (Level 52)|
|Fiend Pale Rider (Level 57)||Fiend Mother Harlot (Level 64)|
|Fiend Trumpeter (Level 73)||King Demi-fiend (Level 99)|
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