Nioh - The Queen’s Eyes Main Mission Walkthrough

This page contains a walkthrough on the Main Mission The Queen's Eyes for Nioh on PS5 and PS4. Included are all items, weapons, armor, enemies and bosses encountered in the game.

Nioh and Nioh 2 (including all DLCs) are also bundled in the Nioh Collection on PS5.

Click here to go to the Main Missions Summary page.

Main Mission – The Queen’s Eyes Walkthrough

You’re back in England, so everything’s an extra shade of black. After watching the intro cutscene, head to the shrine to your right to save. You’ll notice that you won’t be able to avail of any of the benefits you had in your previous missions. Head across the archway. Watch out for the two prowling guards. One has a ranged weapon that might be your demise. Keep moving northeast through the next archway until you find a small tunnel. Turn left into the tunnel and enter through the door nearest the exit. Head up the stairs. Keep moving forward.

Taking out the guard, loot the rooms inside the structure, and then look for the stairs leading up. Head up the stairs. A knight is guarding a cell. Take him out. Speak to the man inside the cell to get the small soul stone. . Explore the floor to find some loot.

After doing so, head through the double doors to the northeast (adjacent to the cell door). Remove the piece of wood blocking the door and go through it. Keep moving northeast to find the staircase heading down stairs. In this chamber you will find a shrine.

Head southeast now into a small set of steps. You’ll be in a dark hallway. Head to the corner and you’ll find a chest with some loot. Turn right back into the chamber. Look for the huge metal doors and go through them. Head down the walkway and head southwest. Take out the guards immediately. Make sure to check the area for loot before heading northeast through the large steps into another part of the structure. Inside, you’ll find a knight and a guard. Take them out.

Head up the stairs. After looting the second floor landing, look for the spiral staircase to the southeast. Head up the stairs to the fourth landing, skipping the third (unless you want to loot). On the fourth floor, take out the guards on the balcony. Go through a wooden door to find an office with a chest as well as a searchable desk. Watch out for the knight prowling this area. He wields an axe.

Find the second spiral staircase near the knight and go down. On the third floor, you’ll find a shrine as well as a pair of iron doors locked on the other side. Head up the small stairway to your left and fight the knight. Take him out. Loot the area.

Afterwards, head back through the second spiral staircase and go down to the second floor. Head east and turn right through the walkway with teh two guards. Slice your way through them and look for the spiral staircase that descends downward. In this chamber, you’ll find a set of double doors. Go through them. Destroy the glass chambers if you wish to fight the Yokai hidden within.

Keep moving forward, deeper into the holding chamber. There are test subjects here that could deal a lot  of damage against you, so be careful. Get the Alchemist’s Laboratory Key once you defeat them.

Open the double doors and head up the stairs. Prepare for an intense final boss fight.

Boss Battle – Hundred Eyes

Source: Youtube

Main Article: Hundred Eyes Boss Guide

This eldritch abomination hits you with lasers and homing attacks. It also lashes at you with its gigantic tentacles, but these you can block. Destroy the eyes with one strike, and be wary of his crystal projectiles.

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