Nioh and Nioh 2 (including all DLCs) are also bundled in the Nioh Collection on PS5.
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Hundred Eyes Boss Guide
Considered the Epilogue Main Mission Boss of Nioh, Hundred Eyes emerges during The Queen’s Eyes Mission. This Mission requires that you first finish Yamata-no-Orochi.
Before taking on the mission, it is recommended to endow your weapon with a Fire property, since this pairs well with the Magical Buffs to maximize damage.
Similar to the Giant Centipede, take advantage of striking its rear since it’s the vulnerable spot. This prevents you from suffering too much blows from the lasers and homing attacks he fires up front. Like other bosses that need to be handled by striking their behind, Hundred Eyes may also turn around to deliver a tentacle swipe, which fortunately may be blocked.
He may summon his eyes that fire lasers, however these can be destroyed with a single strike. However, it’s better to eliminate only of them. Avoid the other and focus on Hundred Eyes himself, since he will simply loaf around making him prone to attacks.
One thing to be wary of is his crystal projectiles. Whenever he executes this move, circle around and keep distance of about 15 meters, until these wear off.
Save your Living Weapon for when he is about to summon the laser eyes again for the second time. If you keep on eliminating the small laser eyes, your living weapon’s gauge will replenish. Perform a combo and it will eventually finish him for good.